בשל "הגנת זכויות יוצרים" מובא להלן קישור לתקציר המאמר. לקריאתו בטקסט מלא, אנא פנה/י לספרייה הרפואית הזמינה לך. 

Ketamine is arguably the most interesting drug in our armamentarium. Depending on the dose and setting, ketamine can be used as an anesthetic, analgesic, antidepressant, psychedelic, or psychotomimetic (e.g., to model psychiatric disorders such as schizophrenia).

But what is the interrelationship of these psychoactive properties? Are they all reducible to a single and fundamental cause? Or do they represent a constellation of dissociable traits with distinct underlying mechanisms?

In this issue of Anesthesiology, Olofsen et al. report a study that attempts to dissect the antinociceptive and psychedelic effects of ketamine.