Intraoperative hypotension (IOH) is strongly linked to organ system injuries and postoperative death.

Blood pressure itself is a powerful predictor of IOH; however, it is unclear which pressures carry the lowest risk and may be leveraged to prevent subsequent hypotension.

Our objective was to develop a model that predicts, before surgery and according to a patient’s unique characteristics, which intraoperative mean arterial pressures (MAPs) between 65 and 100 mm Hg have a low risk of IOH, defined as an MAP <65 mm Hg, and may serve as testable hemodynamic targets to prevent IOH.