בשל "הגנת זכויות יוצרים", מובא להלן קישור למאמר בלבד. לקריאתו בטקסט מלא, אנא פנה לספרייה הרפואית הזמינה לך.

Physiological measures of heart failure are common in surgical patients, despite the absence of a diagnosis.

Heart rate (HR) increases during exercise are frequently blunted in heart failure (termed chronotropic incompetence), which primarily reflects beta-adrenoreceptor dysfunction.

We examined whether chronotropic incompetence was associated with myocardial injury after noncardiac surgery.

This was a predefined analysis of an international cohort study where participants aged ≥40 yr underwent symptom-limited cardiopulmonary exercise testing before noncardiac surgery.

Chronotropic incompetence was defined as the ratio of increase in HR during exercise to age-predicted maximal increase in HR <0.6.

The primary outcome was myocardial injury within 3 days after surgery, defined by high-sensitivity troponin assays >99th centile.